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Jen Hansen, Kittie Spears, and Cynthia Nichols have been friends since childhood. They are now approaching forty and their lives have changed, but their insular East Texas town has not. They stay sane by drinking wine in the afternoons, dishing about other women in the neighborhood, and bonding over the heartache of their own encroaching middle age and raising ungrateful teens.

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Visiting her family's South Carolina estate, socialite Gray Godfrey wakes from a night out to an empty bed. Her husband, Paul, is gone, and a thrashing hangover has wiped her memory clean. At first, she's relieved for the break from her tumultuous marriage. But when his car is found abandoned on the highway, Gray must face the truth: Paul is gone.

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A potential worldwide catastrophe looms large, while CIA Officer Jennifer Lear waits in a Berlin café to meet with her agent who has critical information regarding the chilling emerging threat. But the agent is late, and the meeting turns into a frantic struggle to survive, generating many questions about how it all could have gone so wrong: Who exactly is Jennifer Lear?